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2 edition of cytoplasm of hepatocytes during carcinogenesis found in the catalog.

cytoplasm of hepatocytes during carcinogenesis

P. Bannasch

cytoplasm of hepatocytes during carcinogenesis

electron- and lightmicroscopical investigations of the nitrosomorpholine-intoxicated rat liver

by P. Bannasch

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Published by Springer in Berlin .
Written in English


Edition Notes

Statementby Peter Bannasch.
SeriesRecent results in cancer research -- 19
The Physical Object
Pagination105p. :
Number of Pages105
ID Numbers
Open LibraryOL13946960M

Endoplasmic Reticulum Markers. The endoplasmic reticulum (endoplasmic meaning "within the cytoplasm," reticulum meaning "little net" in Latin) or ER is an organelle found in all eukaryotic cells that is an interconnected network of tubules, vesicles and cisternae that is responsible for several specialized functions: Protein translation, folding, and transport of proteins to be used in the. Examples of single-user license include conferences, seminars, presentations, and one-time teaching courses. Examples of multi-user license include books, book chapters, educational material, and other publications with multiple copies. We provide 1 original (JPEG or TIFF) and 1 high-quality optimized image without our logo.

  recommendation: While some degree of nuclear enlargement is frequently seen in mice, particularly as an aging change, the degree of nuclear enlargement and the accompanying enlargement of hepatocytes shown in Figure 1 and Figure 2 are not typically seen in control mice in prechronic studies. In this case it is a potential treatment effect and should be diagnosed and given a severity grade. The livers of all of the animals in this study contained HBsAg + hepatocytes at the time of autopsy; however, the frequency of such hepatocytes was much lower in group 1 animals (– 15%) than in groups 2 and 3 (30–60%), presumably reflecting the destruction of antigen-positive hepatocytes by the immune response and, perhaps, the.

Cholangiocarcinoma (CCA) is a rare biliary-duct malignancy with poor prognosis. Recently, the presence of the human polyomavirus 6 (HPyV6) has been reported in the bile of diverse hepatobiliary diseases, particularly in the bile of CCA patients. Here, we investigated the presence of novel HPyVs in CCA tissues using diverse molecular techniques to assess a possible role of HPyVs in CCA. Hepatocellular carcinoma (HCC) is the most common malignant tumor of males in the world, with an incidence of 1,, new cases a year. It is endemic in Southeast Asia and Sub-Saharan Africa. Risk factors include chronic infection with hepatitis B virus (HBV) and hepatitis C virus (HCV), Aflatoxin .


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Cytoplasm of hepatocytes during carcinogenesis by P. Bannasch Download PDF EPUB FB2

The Cytoplasm of Hepatocytes during Carcinogenesis: Electron- and Lightmicroscopical Investigations of the Nitrosomorpholine-intoxicated Rat Liver (Recent Results in Cancer Research) [Bannasch, Peter] on *FREE* shipping on qualifying offers. The Cytoplasm of Hepatocytes during Carcinogenesis: Electron- and Lightmicroscopical Investigations of the Cited by: The Cytoplasm of Hepatocytes during Carcinogenesis Electron- and Lightmicroscopical Investigations of the Nitrosomorpholine-intoxicated Rat Liver Authors: Bannasch, PeterBrand: Springer-Verlag Berlin Heidelberg.

An experimental study by electron and light microscopy using the nitrosomorpholine-intoxicated rat liver. References and a subject index. Well illustrated. The Cytoplasm of Hepatocytes during Carcinogenesis Electron- and Lightmicroscopical Investigations of the Nitrosomorpholine-intoxicated Rat Liver.

von Peter Bannasch. €In den Warenkorb. Lieferung in Werktagen. Bannasch P. The cytoplasm of hepatocytes during carcinogenesis.

Electron and light microscopical investigations of the nitrosomorpholine-intoxicated rat liver. In: Rentchnick P, editor. Recent Results in Cancer Research. Vol. Heidelberg: Springer; pp. 1–Cited by: Cytoplasm, the semifluid substance of a cell that is external to the nuclear membrane and internal to the cellular membrane, sometimes described as the nonnuclear content of protoplasm.

In eukaryotes (i.e., cells having a nucleus), the cytoplasm contains all of the organelles. Therefore the ratio aminoacid incorporation cytoplasm/nucleus is characterized by lower values than in controls. But this phenomenon is not specific for carcinogenesis or tumors, since the same effect can be observed under several conditions such as in hepatocytes.

Bannasch P () The cytoplasm of hepatocytes during carcinogenesis. Recent Results Cancer Res –10 Google Scholar Bannasch P () Die Cytologie der Hepatocarcinoge-nese. Romil Saxena MD, FRCPath, in Practical Hepatic Pathology: a Diagnostic Approach (Second Edition), Hepatocytes. Hepatocytes appear as irregular polyhedral cells containing a roughly spherical nucleus that constitutes 5% to 10% of cell volume and contains one or more prominent nucleoli.

Hepatocytes range in size from 20 to 30 μm; the size being influenced by a number of factors such as. Morphological markers: During hepatocarcinogenesis at least 4 different types of altered hepatocytes can be distinguished in routine hematoxylin- and eosin-stained tissue sections: 1. clear cells, 2.

acidophilic cells, 3. vacuolated cells, and 4. basophilic (tumour) cells. Under the electron microscope, the clear cells can be characterized by.

The continuous feeding of the carcinogenic aminoazo dye DAB to rats produces hyperbasophilic foci in the preneoplastic livers. After injections of thymidine-3 H into the rats, such foci were isolated from the livers and studied by radioautography with the phase-contrast and electron these foci, the only cells found to be proliferating, as determined by the uptake of thymidine from book Cell Growth and Oncogenesis (pp) Early aberrations of energy metabolism in carcinogenesis.

The cytoplasm of hepatocytes during carcinogenesis. Depending upon the specific xenobiotic responsible, hypertrophic hepatocyte cytoplasm may have a pale, ground glass appearance or be granular and intensely eosinophilic, especially following exposure to peroxisome proliferators (Figure 5).

Figure 6 is a concurrent control liver for comparison with Figure 5. Marked hypertrophy with associated. normal hepatocyte. Balloon cells: markedly enlarged hepatocytes.

Cytoskeletal elements start clumping, becoming rope-y and ubiquinated. Hyaline or intermediate filaments = Mallory bodies.

apoptotic body. Pyknotic nucleus \(condensed chromatin\). Hyper-eosinophilic cytoplasm. Becoming condensed and small. TGF-β represents a major growth inhibitory signal in normal epithelial cells such as hepatocytes ().In the context of cell cycle control, the most important targets of action by TGF-β are the genes encoding the two CDK inhibitors p15 INK4B and p21 Cip1, that inhibit CDKs and downregulate c-Myc expression ().As the cytostatic effects of TGF-β are reversible, pSmad3C is negatively regulated.

LifeNet Health Human Primary Hepatocyte FAQs. Why would you use primary human hepatocytes as opposed to cell lines. Unlike most hepatic cell lines, which by definition are altered or transformed cells, primary hepatocytes retain most, if not all, of their original biochemical and molecular signaling pathways and phenotypic gene expression profiles, including important transcription factors and.

Bannasch P. The cytoplasm of hepatocytes during carcinogenesis. Electron and light microscopical investigations of the nitrosomorpholine-intoxicated rat liver.

Recent Results Cancer Res. ; – [Google Scholar]. Structure. The typical hepatocyte is cubical with sides of μm, (in comparison, a human hair has a diameter of 17 to μm).

The typical volume of a hepatocyte is x 10 −9 cm Smooth endoplasmic reticulum is abundant in hepatocytes, whereas most cells in the body have only small amounts. Hepatocellular carcinoma (HCC) is a malignant solid tumor that arises from the major cell type in the liver: the hepatocyte.

HCC is the most common type of primary hepatic tumor; it represents approximately 6% of all malignancies and is the fifth most common tumor worldwide [].Nearly all types of primary liver tumors known to occur in humans can be reproduced by chemicals in laboratory animals.

The study of in vitro carcinogenesis of human hepatocytes has shown that only the introduction of SV40 large T antigen can successfully immortalize cells. A major difficulty in the in vitro induction of carcinogenesis of human hepatocytes is the inadequacy of the available methods of culturing human hepatocytes.

To solve this problem, methods. Based on the current paradigm that inflammation promotes HCC carcinogenesis and the fact that carcinogen DEN induces extensive death of hepatocytes 5.

Although HBV does not cause direct cytopathic effects, the oncogenic role of HBV might involve a combination of direct and indirect effects of the virus during the multistep process of liver carcinogenesis.

In this regard, hepatocyte proliferation driven by host immune responses is a recognized driving force of liver cell transformation, as. HGF was also observed in hepatocytes with strong atypia in two patients (Fig.

4b). In cancerous regions, HGF was detected in infiltrating mesenchymal cells and in the cytoplasm and cell membranes of cancer cells in four (80%) of five patients (Fig. 5a–c). Carcinomas of these four patients were highly or moderately differentiated, single.